Found 23 of ic50 data for polymerid = 10485,10592,10684 TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 26nMT: 2°CAssay Description:IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...More data for this Ligand-Target Pair
3D Structure (crystal)TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 31nMT: 2°CAssay Description:IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 38nMT: 2°CAssay Description:IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 38nMT: 2°CAssay Description:IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 40nMT: 2°CAssay Description:IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (strain HC-J4) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 190nMpH: 7.5 T: 2°CAssay Description:Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (strain HC-J4) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 220nMpH: 7.5 T: 2°CAssay Description:Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (strain HC-J4) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 240nMpH: 7.5 T: 2°CAssay Description:Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (strain HC-J4) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 280nMpH: 7.5 T: 2°CAssay Description:Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (strain HC-J4) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 290nMpH: 7.5 T: 2°CAssay Description:Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (strain HC-J4) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 410nMpH: 7.5 T: 2°CAssay Description:Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 530nMT: 2°CAssay Description:IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (strain HC-J4) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 930nMpH: 7.5 T: 2°CAssay Description:Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 930nMpH: 7.3 T: 2°CAssay Description:To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 1.10E+3nMpH: 7.3 T: 2°CAssay Description:To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 1.40E+3nMpH: 7.5Assay Description:NS5B RNA polymerase reactions for IC50 determination were performed in 96-well microtiter plates in 20 μL reactions containing assay buffer (50 ...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 2.10E+3nMpH: 7.5Assay Description:NS5B RNA polymerase reactions for IC50 determination were performed in 96-well microtiter plates in 20 μL reactions containing assay buffer (50 ...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland
US Patent
Janssen Ireland
US Patent
Affinity DataIC50: 2.42E+3nMT: 2°CAssay Description:IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 6.70E+3nMpH: 7.3 T: 2°CAssay Description:To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: >2.00E+4nMpH: 7.3 T: 2°CAssay Description:The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 4.00E+4nMpH: 7.3 T: 2°CAssay Description:The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 5.10E+4nMpH: 7.3 T: 2°CAssay Description:To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ...More data for this Ligand-Target Pair
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 6.50E+4nMpH: 7.3 T: 2°CAssay Description:The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...More data for this Ligand-Target Pair
